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Homework- answer questions 1-3 in about 600 words. Question 4 is optional and just for those students interested in the topic. It could also form the basis for your final paper!

1. Imaging biomarkers:
a. What is considered a good imaging biomarker?
b. Please provide 2 examples of imaging biomarkers for neurological diseases (e.g., Alzheimer’s disease; Parkinson’s diseases; multiple sclerosis).

2. Mapping of structural and functional networks of human brains:
a. What are the differences between structural connectivity networks and functional connectivity networks of human brains?
b. Do neurological disorders affect both structural and functional connectivity networks at the same time? or one of them first?

3. What are the advantages and disadvantages of early disease detection?

4. (Optional: for highly motivated students only) Many different types of imaging modalities have been used to study Parkinson’s disease, as reviewed by [1,2]. Which imaging modality would you consider the best of all?

  1. Carol P Weingarten, Mark H Sundman, Patrick Hickey, and Nan-kuei Chen. Neuroimaging of Parkinson’s disease: Expanding views. Neuroscience and Biobehavioral Review. 2015 Dec;59:16-52. doi: 10.1016/j.neubiorev.2015.09.007. Epub 2015 Sep 26.
  2. Usman Saeed, Jordana Compagnone, Richard I. Aviv, Antonio P. Strafella, Sandra E. Black, Anthony E. Lang, and Mario Masellis. Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts. Translational Neurodegeneration. 2017 Mar 28;6:8. doi: 10.1186/s40035-017-0076-6. eCollection 2017.

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